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Most adverse events were mild-to-moderate and gastrointestinal in nature

Hypertension, dyslipidemia, prediabetes, obstructive sleep apnea, and osteoarthritis are all qualifying comorbidities and all of them improve meaningfully with 1015% weight reduction

Discuss Adjustments: Your doctor may suggest a slightly higher dose or a change in timing

T2-weighted imaging showed that the off-center region within the control grafts exhibited liquefaction-equivalent hyperintense signals with recognizable boundaries

The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function