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This process is inherently "leaky," naturally producing small amounts of ROS

Neuromelanin released from dying DA neurons in the SNpc activate microglia, increasing the sensitivity of DA neurons to oxidative stress-mediated cell death (Halliday et al., 2005

Recently, subpopulations of SST INs, including neuropeptide Y (NPY) SST-INs, have been implicated in cognitive resilience, with overrepresentation of this cell-type in human cortex linked to resilience against AD neuropathology 14

We analyzed how much of the available renewable water in a watershed were using up for over 15,000 watersheds worldwide for each month in wet and in dry years

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