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iNOS appears to be a critical factor in regulating cytokine (tumor necrosis factor-alpha/TNF) induced lipolysis that occurs during chronic inflammation [162]

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Figure 3 Oligomeric A 40 Induces Inflammation Which Is Modulated by GGC Treating human brain cells with oligomeric A 40 significantly decreased the level of the anti-inflammatory cytokine IL-10 (Figure 4A) and increased the levels of the pro-inflammatory cytokines, TNF-, IL-6 and IL-1 compared to non-treated cells (Figures 4BD)

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CzarnowickiTHeHKruegerJGGuttman-YasskyE.Atopic dermatitis endotypes and implications for targeted therapeutics