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The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords
This matched study included 1,648 patients in the semaglutide group and 1,649 in the placebo group from the SUSTAIN 6 trial, as well as 4,949 patients in the dulaglutide group and 4,952 in the placebo group from the REWIND trial
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In research models, GLP-1 receptor activation is associated with glucose-dependent insulin secretion, suppression of glucagon release, slowed gastric emptying, and reduced food intake through central appetite-regulating circuits
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