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The phrase without the involvement of any other agency (although, rarely, complement is included) indicates that neutralization is typically measured in vitro by incubating antibodies, virus particles and target cells together and demonstrating reduced infection

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Thymosin Alpha-1 is an immune-modulating compound that is formally approved as a pharmaceutical product in more than 30 countries including Italy, China, and several Southeast Asian nations for the treatment of hepatitis B, hepatitis C, and as an immune adjuvant in oncology