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Precursors entering the gut are absorbed by the upper gastrointestinal tract during oral administration and are unavailable to the microbes in the large intestine

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This self-perpetuating loop drains the cells glutathione reserves, as the antioxidant is rapidly consumed in a desperate attempt to neutralize the surging ROS

The collagenase model replicates the matrix disorganization and degenerative pathology of clinical tendinopathy more closely than transection models, strengthening the relevance of the findings to the human chronic tendinopathy condition

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