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Description

Wheeler MB, Lu M, Dillon JS, Leng XH, Chen C, and Boyd AE, 3rd

Description IGF-1 LR3 is a synthetic elongated analogue of insulin-like growth factor 1 (IGF-1), engineered with an N-terminal arginine-based extension that reduces IGF-binding protein (IGFBP) affinity and extends plasma half-life relative to endogenous IGF-1

This in vitro cell culture study demonstrated receptor activation through the cAMP signaling pathway, which is a key second messenger system in G-protein coupled receptor signaling