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doi: 10.1038/s41586-021-03638-5

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On the contrary, 5-MTHF can function without going through the folate metabolism because it is a natural and active form of folate

While the target population in this NMA is different from the one considered by Nuhoho et al., findings in terms of GLP-1 RAs relative efficacy and ranking are consistent between the two studies, indicating that once-daily oral semaglutide is an efficacious add-on therapy for a broad population with T2D, including people with advanced disease