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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

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dose absorption ratio Cyanocobalamin requires conversion to metabolically active cobalamin

Self-Administration Guidelines for Home Use For patients who need ongoing vitamin B12 injections, self-administration at home can be convenient

4 weeks 1 vial 28 doses needed