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The requirement for cationic CPP in our study is consistent with findings from other studies, where CPPs with hydrophobic motifs did not significantly enhance cell uptake 60

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10 Recently, several clinical trials have shown the potential effects of these medications in not only in glycemic control but also in the improvement of cardiovascular outcomes, weight loss, osteoarthritis, 11 metabolic dysfunctionassociated steatohepatitis (MASH), 12 Parkinsons disease, 13 chronic kidney disease (CKD) 14 and obstructive sleep apnea