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This medicine may cause serious damage to the optic nerve (the nerve that connects the eye to the brain) in these individuals

Some recent studies have noted more cases of NAION, a sudden loss of vision linked to reduced blood flow in the optic nerve, in people taking semaglutide

This implies that peripherally restricted melanocortin agonists may not alter blood pressure

Furthermore, increased doses of liraglutide (3 mg) were evaluated in Phase 3, and the result showed that overweight to obese participants experienced a weight decrease of 6% when treated with 3 mg of liraglutide, compared to those on a placebo

However, the medications themselves should be paused during the conception window because their effects on GLP-1 receptors in reproductive tissues are not fully understood in humans