(Wilding et al., NEJM, 2021 PubMed: 33567185) STEP 2 Trial (2021) In patients with both obesity and type 2 diabetes, semaglutide 2.4 mg produced mean weight loss of 9.6% versus 3.4% with placebo at 68 weeks
the outcomes in the hierarchy were generally consistent with those found in the placebo-controlled trials
Fang M, Jeon Y, Echouffo-Tcheugui JB, Selvin E (2023) Prevalence and management of obesity in U.S
For NHS-funded treatment, patients must have a BMI of 35 kg/m (or 32.5 kg/m in certain ethnic groups) with at least one weight-related comorbidity, or a BMI 30 kg/m (27.5 kg/m in certain ethnic groups) with at least one weight-related comorbidity and a referral to a specialist weight management service
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