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Although it is associated with a lower incidence of peptic ulceration and gastrointestinal bleeding than non-selective NSAIDs, valdecoxib confers a higher risk of serious cardiovascular events and was withdrawn from the market in 2005 because of an excess incidence of myocardial infarction and stroke at high doses or after prolonged use

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A considerable proportion is excreted in unchanged form and another in the form of conjugated metabolites