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The resulting oxidized peptide has altered folding and reduced biological activity

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Emerging evidence suggest that both are controlled redox signaling mechanisms

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Nitrosative stress leads to the overproduction of RNS, including nitric oxide (NO) which triggers an immune response, and its derivatives: nitrous acid (HNO 2 ), nitrogen dioxide (NO 2 ), and nitric acid (HNO 3 ) ( 2 - are produced in the reactions catalyzed by iNOS, and O 2 - reacts with NO to generate peroxynitrite (ONOO ) with strong oxidizing and nitriding properties ( and other RNS (NO 2 ) ( It should also be noted that NO plays a dual role in the pathogenesis of asthma