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Excess Fe 2+ catalyzes the production of hydroxyl radicals (OH) through the Fenton reaction, thus triggering a chain reaction of lipid peroxidation ( ACSL4 ) and lysophosphatidylcholine acyltransferase 3 ( LPCAT3 ), promotes the enrichment and remodeling of polyunsaturated fatty acids (PUFAs) in membrane phospholipids ( GPX4 glutathione (GSH) antioxidant system will damage the detoxification of lipid hydroperoxides, resulting in the fatal accumulation of lipid peroxidation products ( 2.2 Pathological mechanisms in DKD In DKD, the susceptibility to ferroptosis is jointly driven by iron metabolism disorder, impaired antioxidant defenses, and enhanced lipid peroxidation (Figure 1)

The authors hypothesized that resveratrol could mitigate these alterations by regulating Thoc5, a factor involved in RNA transport and processing

Fendrick AM, Greenberg BP

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