This article was submitted to Predictive Toxicology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Notably, the overall trend in fasting C-peptide/glucose ratios followed a hyperbolic profile during the first year after diagnosis, with only moderate individual variation
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Early-stage changes such as hypertension, endothelial dysfunction, systemic inflammation, and accelerated atherosclerosis are responsible for increased cardiovascular risks and hasten the onset of ESRD (Lai et al., 2020)
