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Although there have not been many studies, the effects of smoking cessation on endothelial function have been shown

66, 91, 92, 93 Tobacco smoke contains many reactive oxygen species (ROS), which can overwhelm the lung's natural antioxidant defense mechanisms in the epithelial lining fluid and target underlying airway tissues, including the subepithelial DC network

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This close-up of the surface of a dissected lung shows multiple cavities filled with heavy black carbon deposits