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While specific requirements can vary by provider, clients are commonly considered good candidates if they meet one of the following criteria: A BMI of 30 or higher (classified as obesity) A BMI of 27 or higher with at least one weight-related health condition, such as high blood pressure, high cholesterol, type 2 diabetes, prediabetes, or sleep apnea In addition, candidates should be in overall stable health, not pregnant or breastfeeding, and not have a personal or family history of certain medical conditions such as medullary thyroid carcinoma or MEN2 (Multiple Endocrine Neoplasia type 2)

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GLP-1 medications and significant weight loss can increase the risk of gallstones, which may present with right upper abdominal pain, fever, and sometimes jaundice

Diabetes Care 36:29452951 Fonseca VA, Alvarado-Ruiz R, Raccah D et al (2012) Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)

These limitations do not invalidate the findings, but they do mean that the evidence is preliminary rather than definitive