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Thyroid C-Cell Tumors: In rats, Zepbound caused a dose-dependent and treatment-duration-dependent increase in thyroid C-cell tumors

Additionally, the treatment was associated with decreased expression magnitudes of pro-inflammatory cytokines, including IL-17, IL-23, and TNF-, in the affected skin tissue [201]

2.4 Recommended Dosage in Patients with Renal Impairment The recommended dosage of XIGDUO XR in patients with an estimated glomerular filtration rate (eGFR) greater than or equal to 45 mL/min/1.73 m2 is the same as the recommended dosage in patients with normal renal function

This broader view helps ensure that weight loss supports physical well-being rather than creating new challenges through rapid or poorly supported change

A waist circumference above 40 inches in men or 35 inches in women indicates elevated cardiovascular and metabolic risk regardless of BMI