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Annu Rev Pharmacol Toxicol 47:14383, PMID: 17029566 Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N (2010) Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload

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L-carnitine is given to patients receiving dialysis for kidney failure and is considered very safe.L-carnitine (LC) administration has been recommended for specific indications in dialysis patients, including epoetin-resistant anemia, intradialytic hypotension, cardiomyopathy, fatigue, muscle weakness, and exercise performance

In terms of metabolic regulation, GLP-1RAs exert their effects through various pathways, including increasing insulin sensitivity, maintaining glucose homeostasis, promoting weight control, and improving lipid metabolism