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Although nanomedicine significantly improves melatonins bioavailability in the CNS, further pharmacokinetic, pharmacodynamic, and clinical studies (with therapeutic doses above 10 mg per day) are necessary to ensure long-term safety

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However, limitations included the restricted inclusion criteria (eGFR range of 2075 mL/min/1.73 m 2 and albuminuria requirements), which limit generalizability to patients with higher or lower eGFR or preserved eGFR without albuminuria

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