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The -1 subcluster exhibited increased expression of several mitochondrial genes as well as stress-related genes, such as XBP1 , ferritin heavy chain 1 ( FTH1 ), and ferritin light chain ( FTL ), in response to liraglutide treatment

Many patients report experiencing fluctuating effects from Ozempic during the week, particularly regarding appetite suppression and gastrointestinal symptoms

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Preclinical studies in animal models have demonstrated that survodutide effectively activates both GLP-1R and GCGR, resulting in reduced body weight, slower gastric emptying, decreased energy intake, increased energy expenditure, and improved glucose tolerance [86]

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