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Assessing both the abundance and relative balance of core commensal organisms, such as Bifidobacterium, A
The New England Journal of Medicines publication of the STEP trial revealed more than 50% of trial participants lost 15% of their body weight, and between 33-40% of participants lost 20% of their body weight
Even in this last trial, CRP levels were significantly reduced compared to placebo (respectively 42.0% vs 12.8%, estimated treatment ratio 0.67
In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone
Research data supporting these mechanisms is widely available in global biomedical databases
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