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In previous studies, p53 TAD was shown to significantly influence the DNA selectivity of p53 DBD, with the acidic residues of TAD believed to contribute to this selectivity through interactions with the basic residues of DBD 54

Spermatozoa do not possess BER enzymes, such as apurinic endonuclease 1 (APE1) and x-ray repair cross-complementing protein 1 (XRCC1)

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As expected, we observed that the lifespan of WT hermaphrodites was significantly reduced upon mating (Fig

On the other hand, in the SUSTAIN 6 trial, the effects on plasma lipids of the most powerful of the GLP-1RAs, semaglutide, were not remarkable