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22 and Horvth et al

These considerations draw from criteria typically used to interpret and establish causation based on epidemiological data, and which are adapted from the approach taken in the 2014 Surgeon Generals report on smoking and health (HHS, 2014

As per the estimates, roughly 6.5 trillion cigarettes are sold every year

Flavored little cigars sales, for example, increased by nearly 50% after they were excluded from 2009 regulations