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More than three decades after the discovery of GLP-1, the hormone has transformed the treatment of obesity, diabetes, and cardiometabolic disorders that affect more than a billion people worldwide

The previous interactions contribute to the activation of the peripheral immune system and primes CNS microglia, creating a neuroinflammatory environment that aggravate behavioral deficits (Manda et al., 2012

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Nevertheless, before initiating SGLT2 inhibitor therapy one should consider factors in the patient history that may predispose them to the need for amputations, such as a history of prior amputation, peripheral vascular disease, severe neuropathy, and diabetic foot ulcers and weigh the risks and benefits of therapy (package insert)