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50, 51, 52 It is also known that the adaptive response induced by 4-hydroxynonenal, one of the important determinants of oxidative stress, is positively mediated by gene expression of cyto-protective protein (Nrf2/Keap-1) pathway

I basically share the same philosophy in nutrition as you did then and now

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Storage and handling Before reconstitution (powder) Storage : Refrigerate at 2-8C (36-46F) Shelf life : 2-3 years when properly stored Stability : Very stable as lyophilized powder Travel : Can survive room temperature for short periods (days) After reconstitution (liquid) Storage : Refrigerate immediately at 2-8C Shelf life : 28 days with bacteriostatic water Stability : Degrades over time, use within 28 days Travel : Keep cold (use cooler with ice packs) Light : Protect from direct light (store in box) Handling tips Always use clean technique Don't contaminate vial top Use new needle each time Don't freeze Don't shake vigorously Mark reconstitution date on vial Common mistakes with 5mg vials Using wrong water Mistake : Using sterile water instead of bacteriostatic water

Because mitochondria utilize about 90% of inhaled oxygen, they are highly vulnerable to free radical oxidative damage