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A complex interplay between the gut microbiota, the parasympathetic nervous systemwith a prominent role of vagus nerve-immune system and the different cells located in the gut is continuously occurring [69]

Similarly, studies have shown that amygdalin treatment through the NRF2/ARE signaling pathway can significantly inhibit ferroptosis and oxidative stress in HRECs stimulated by high glucose (222)

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While these immediate effects can be encouraging, they are often short-lived unless supported by regular injections and other complementary treatments or lifestyle changes