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They are potent pyrogens (fever-inducers) and can cause significant non-specific inflammatory responses in many biological systems, including cell cultures

The Science: GLP-1 Drugs, Cartilage, and Bone Health Are More Intertwined Than Anyone Expected The most exciting recent finding comes out of Cell Metabolism, where researchers showed that semaglutide may directly reverse cartilage damage in osteoarthritis, and here is the key part: that benefit appears to be independent of weight loss

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We suggest that reduced GPx1 in monocytes recruited to the gut and intestinal macrophages renders these cells vulnerable to reactive oxygen species-evoked ferroptosis cell death and that unraveling the participation of this pathway in Crohns disease may reveal novel therapeutic approaches to this chronic condition

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