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Nick Cigarette ads featuring the kid-friendly figure of Santa Claus have been numerous, including this 1920 ad for Murad

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A challenge of observational studies is potential confounding, because without randomization, certain factors (confounders) may be systematically and unequally distributed across e-cigarette users and non-users

less than 2) showed no significant correlation between age ( P = 0.063), walking exercise ( P = 0.609), BMI ( P = 0.827), diarrhea ( P = 0.298), constipation ( P = 0.648), history of chronic diseases ( P = 0.874), history of gastrointestinal ( P = 0.980) or gynecological surgeries ( P = 0.293) with high BBPS