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Particularly when you compare it to the risk of eye disease in the setting of diabetes, which is where most of this question has been studied

In contrast, induction of ER stress via central administration of thapsigargin completely abolished the RYGB-mediated improvement in leptin sensitivity, without affecting control animals, highlighting ER stress as a key regulatory factor in the beneficial effects of RYGB on hypothalamic leptin signaling [97]

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Understanding this distinction helps prevent misinformation and supports informed consent

Reduce the substrate, reduce the gas