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HCG and Hyperglycosylated Isoform Research Hyperglycosylated hCG (hCG-H) is an over-glycosylated isoform of hCG that comprises up to 90% of total hCG measurable in serum and urine during the first 23 weeks of pregnancy when invasive trophoblast activity is at its highest dropping to less than 5% of total hCG by the end of the first trimester