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For further biological evaluation, co-culture systems and reconstructed skin models should be adopted to screen for the ability of the novel compounds to interfere with the melanogenesis process, especially following stimuli including UV irradiation, exposure to a-MSH or proinflammatory cytokines

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Expert Opin Pharmacother 18(14):14331438

Organelle clearance during maturation of erythrocytes is associated with the loss of components of the cell death machinery A growing number of studies indicate that mature erythrocytes have a precisely structured RCD machinery comprising of several lethal subroutines with clearly defined molecular mechanisms

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