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In rare cases, semaglutide has been associated with pancreatitis (inflammation of the pancreas)

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(2016) Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

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This local gut distribution of GLP-1 receptors supports a potential bidirectional interaction between GLP-1 signaling and the gut microbiota, which could potentially contribute to the therapeutic benefits observed