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DAF-16/FOXO is a key downstream transcription factor of insulin/IGF-1 signaling pathway and has been implicated in several longevity-affecting regimens, including lifespan extension mediated by germline loss 6,43,44,45

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The cAMP accumulation was measured using a cAMP Gs Dynamic Kit (Cisbio) and EnVision reader (PerkinElmer)

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The resulting product was subsequently located to a light-protected environment for storage and kept at a temperature of 4 C

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