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106 HIF signaling pathway Hypoxia-inducible factors (HIFs), consisting of an oxygen-sensitive subunit and a constitutively expressed HIF-1 subunit, are major regulators of adaptive responses to hypoxia and directly activate the expression of multiple target genes to maintain cellular oxygen homeostasis

While preclinical and clinical studies have reported anti-metabolic and anti-inflammatory benefits with a favourable safety profile, further evidence from long-term and large-scale trials is necessary to guide clinicians in real-life scenarios