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Additionally, brain fluorescence images taken 8 h after injection of T7-LNP@YHV984 showed that the particles primarily accumulated in microglia, confirming the targeting specificity of T7-LNP@YHV984 (Fig

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At the same time, the destruction of the myelin structure leads to the release of antigenic components such as myelin basic protein (MBP), which subsequently activates microglia and infiltrating T cells (63)