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Ceramide synthases in cancer therapy and chemoresistance
To further explore the role of SNX2, we conducted all-atom molecular dynamics simulations, which revealed that the AH domain of the SNX1SNX2a complex resists membrane insertion, as the average AHmembrane distance does not decrease over the course of the simulation (Supplementary Fig
Studies show that its angiogenic effect might be due to the stimulation of VEGFR2, which is a receptor present on the surface of cells that mediates the NO signaling pathway
doi: 10.1371/journal.pbio.0050177 586 DecodeME
Synthetic antibiotics have a speedy therapeutic impact when used to treat microbial infections, but they also represent a substantial risk of gastrointestinal and renal toxicity, and microbial resistance
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