Of the records screened, 46 studies were excluded as they were non-clinical studies (including reviews, editorials, and or conference abstracts), 121 studies were excluded because those studies involved non-human subjects, 28 studies were excluded as they were not conducted in AD or MCI patients, 1 study was excluded as it did not have a healthy control group, and 14 studies were excluded as they did not measure GSH in the brain
Studies have connected low GSH levels to mitochondria cell death
This is significant because current lupus nephritis management relies heavily on immunosuppressants (mycophenolate, cyclophosphamide, voclosporin) and biologics (belimumab, rituximab)
The response to treatment in psoriasis vulgaris may be correlated with the levels of antioxidant GSH activity which may be increased in cases who are not or poorly responding to therapy
Cell viability was assessed by MTT assay, apoptosis by TUNEL staining and Western blotting, oxidative stress by ROS detection and measurement of glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)
