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IGF-1 DES has an ultra-short half-life of about 20 to 30 minutes but approximately 10 times the potency at receptor sites compared to native IGF-1

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Fat-Targeting Peptides: AOD-9604 and Tesamorelin Some peptides specifically target fat metabolism: AOD-9604 A fragment of human growth hormone designed to burn fat without affecting blood sugar levels

However, despite low intra-portal insulin levels, low IGF-I and increased fat mass and decreased lean body mass, their glucose tolerance and insulin sensitivity remains unaffected and in fact, is comparable to normal controls (151, 152)