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In this two-tier screening approach, BBB-PAMPA was first employed to eliminate compounds with poor passive permeability, followed by MDR1-MDCK I to screen out P-gp efflux transporters' substrates
Liver function must be adequate, as the kidneys and liver process these medications, and significant organ impairment requires careful medical consideration
We explain why it's important to ensure you're getting enough, possible symptoms of deficiency, and how to top up levels if needed
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