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En estudios clnicos con RYBELSUS de hasta 18 meses de duracin en los que participaron 6,352 pacientes con diabetes tipo 2, se notificaron acontecimientos adversos relacionados con retinopata diabtica en proporciones similares en pacientes tratados con semaglutida (4.2%) y con los comparadores (3.8%)

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Physicians and researchers say there is no robust clinical evidence that semaglutide or tirzepatide are effective at very small doses, and the drugs arent proven to help patients with many marketed symptoms