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Hruska, P
Furthermore, the clinical heterogeneity of PD, along with the absence of definitive diagnostic biomarkers in early stages, complicates patient stratification and endpoint definition in trials (see details in [15])
Selenium Supplementation (Critical for Glutathione Recycling) Why it works: Selenium is a cofactor for glutathione peroxidase (GPx) , the enzyme that uses glutathione to neutralize hydrogen peroxide and recycles oxidized GSSG back to reduced GSH
NAPQI Formation Highest in FIRST Trimester 43% HIGHER The same Brookhuis 2021 study found: The estimated molar dose fraction of NAPQI was the highest in the first trimester (median (IQR): 11 (9.113.4%), followed by the second (9.0 (7.511%)) and third (8.2 (6.810.1)) trimester compared with non-pregnant women (7.7 (6.49.4%)).[] **This represents a 43% INCREASE in toxic NAPQI formation in the first trimester** (11% vs 7.7%)precisely when the fetal brain is most vulnerable and undergoing critical early development
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