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Interestingly, we observed that SPF mice exhibited more locomotion during the fasting state than the ABX mice (Supplementary Fig

The results of this study revealed no significant changes in the frailty biomarkers: IL-6, TNF-, and IGF-1

Heart failure Analysis of myocardial samples from patients with ischemic and dilated cardiomyopathy in the terminal stage of heart failure, as well as from heart donors without heart disease, found that the downregulation of multiple mitochondrial quality control genes, including LONP1, is closely related to heart failure [63]