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Note: Never stop your prescribed medication or significantly change your dosage without first consulting your healthcare provider

Similar observations have been reported in animal models, including mice

Co-solvents, surfactants, chelating agents, bulking agents, pH modifiers and other formulation ingredients typically used to stabilise biologic drugs can have an impact on the leaching of organic compounds from rubber stoppers.2 As injection device designs evolve to accommodate a broadening range of challenging drugs, often requiring the mitigation of high injection forces for delivery, the plunger stopper has the potential to contribute to the combination products functional characteristics, including glide force, efficacy and safety

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