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As discussed above, exploring the molecular mechanisms underlying drug resistance by performing genomic analyses, identifying the expression of resistance genes, and identifying epigenetic alterations, can improve understanding of the drivers of drug resistance, which can include various risk factors in the history of cancer patients

This bypasses the energy-intensive de novo synthesis pathway

All patients were then followed until death or end of follow-up

Results: From 28 patients with unresectable HCC, 92.8% were classified as Child-Pugh (CP)-A, 64.2% as Barcelona Clinic Liver Cancer (BCLC)-C