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[The benefit] has to be tempered with the reality of being able to pay. If semaglutide receives a new indication from the FDA to treat CKD, Michos said, it could lead to a greater push from clinicians in multiple specialties to screen for the disease and identify it earlier

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Based on which cofactor is used, the enzyme may be NAD + specific ( EC 1.4.1.2 ), NADP + specific ( EC1.4.1.4 ), or able to use either cofactor ( EC 1.4.1.3 )