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For RFS, the survival probabilities at five and 10 years were 95% and 90.9% with GLP-1RAs and 93.8% and 89.9% with SGLT2 inhibitors, respectively

It is synthesized intracellularly from glutamic acid, cysteine, and glycine in mammalian tissues

GLP-1 RAs enhance the regulatory mechanisms of the hypothalamic-pituitary-ovarian axis, affecting LH surges or reductions induced by estrogen aromatization in adipose tissue, and subsequently modulating LH and FSH levels that drive ovarian androgen synthesis [41]

Statements Author contributions Q-XL and J-DX wrote the manuscript

Adipose tissue, a target of GLP-1 agonists, plays a key role in testosterone production