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Clinical implications and research priorities When considering the use of GLP-1 RAs in patients with IBD and comorbid obesity or diabetes, practising clinicians need to recognise the need for shared decision-making that weighs metabolic benefits against limited prospective efficacy data and evolving safety data

Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease

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A landmark randomized, double-blind, placebo-controlled Phase 2 study conducted in the United States enrolled 338 adults with obesity or overweight conditions across multiple dosing regimens