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Biologics, including GLP-1 agonists, are typically derived from genetically modified animal cells or synthesized using advanced techniques and specialized equipment to create proteins from scratch

Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on scientific issues related to definition

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In individuals with obesity, the brain's reward centres may respond more intensely to food cues, whilst satiety signals may become blunted

The mechanism involves inhibition of catechol-O-methyltransferase (COMT), which extends norepinephrine activity and slightly increases metabolic rate